Palonosetron interMediater G

Palonosetron interMediater G - Names and Identifiers

Name	N-(1-azabicyalo[2,2,2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1S-ylcarboxamine
Synonyms	N-(Quinuclidin-3-yl) Palonosetron interMediater G -1,2,3,4-tetrahydronaphthalene-1-carboxamide N-(Quinuclidin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide N-1-azabicyclo[2.2.2]oct-3-yl-1,2,3,4-tetrahydro-1-Naphthaleneca N-1-Azabicyclo[2.2.2]oct-3-yl-1,2,3,4-tetrahydro-1-naphthalenecarboxamide N-1-Azabicyclo[2.2.2]oct-3S-yl-1,2,3,4-tetrahydro-1S-naphthalenecarboxaMide N-(1-azabicyalo[2,2,2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1S-ylcarboxamine
CAS	177793-81-6

Palonosetron interMediater G - Physico-chemical Properties

Molecular Formula	C18H24N2O
Molar Mass	284.4
Density	1.17±0.1 g/cm3 (20 ºC 760 Torr)
Boling Point	495.3±34.0 °C(Predicted)
pKa	14.98±0.20(Predicted)
Storage Condition	2-8°C

Palonosetron interMediater G - Introduction

N-(1-azabicyalo[2,2,2]oct-3S-yl)-1,2,3, is a compound often abbreviated as TEMPO. The following is an introduction to the nature, use, formulation and safety information of TEMPO:

Nature:
TEMPO is a solid with a white or yellowish appearance. It is stable at room temperature, but decomposes at high temperatures. It can be dissolved in many organic solvents and forms stable salts with many alkali metals.

Use:
TEMPO is widely used in organic synthesis. It is an effective free radical oxidant and can catalyze oxidation reactions. It can be used as a catalyst for substrate protection reaction, oxidation reaction and free radical reaction in synthesis. It can also be used to improve the selectivity of polymerization reactions and is an important intermediate in the synthesis of many drugs.

Method:
The preparation of TEMPO is achieved by the oxidation reaction of 1,2, 3,4-tetrahydronaphthalene-1s-formamide with amino radicals. The reaction is usually carried out using an oxidizing agent such as sodium chloro hypochlorite (NaClO2) and sodium hypochlorite (NaOCl).

Safety Information:
TEMPO is relatively safe in general, but still need to pay attention to the following matters:
- TEMPO is an irritating compound that may cause irritation in contact with skin and eyes. Therefore, protective gloves and goggles must be worn when using TEMPO.
- TEMPO flammable, avoid contact with fire. Should be stored in a cool, dry place, and away from combustibles and oxidants.
-When using TEMPO, you must have good ventilation conditions to avoid excessive inhalation of its gas.
- TEMPO should be kept away from children and pets and properly dispose of the residue after use.

The information provided here is for reference only. In practical applications, operators should follow appropriate operating procedures and safety precautions when using TEMPO.

Last Update：2024-04-09 20:48:19